The Deutsches Röntgen-Museum in Remscheid-Lennep (Germany) has been safeguarding Wilhelm Conrad Röntgen’s personal estate, including his photographic collection, for many years. The ongoing cataloging project, in collaboration with various partners, aims to systematically document and make accessible the photographic holdings via the museum-digital.de platform. The estate comprises various types of photographs spanning different periods, shedding light on Röntgen’s roles as a researcher, photographer, and family man. The project faces challenges in categorizing and describing the images, particularly due to the lack of contemporary captions and unclear motifs. The meticulous documentation of Röntgen’s experiments on glass negatives reveals his scientific rigor, with efforts made to correlate images with his publications for identification. The timing of his experiments and photography sessions also unveils different facets of his personality and working methods. With the help of modern technology, many obstacles to cataloging the collection were overcome, and new insights were gathered. In this preliminary report, the highlights of this study are presented.